Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has lead to the use of synaptophysin immunostaining for quantification of synapses.The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.Synaptophysin can refer both to the vesicle membrane protein.

Human Anti-synaptophysin antibody (SYP-Ab) ELISA Kit has been pre-coated with an antibody specific to SYP-Ab. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated SYP-Ab and incubated. The competitive inhibition reaction is launched between with HRP labeled SYP-Ab and unlabeled SYP-Ab with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of SYP-Ab in the sample. The color development is stopped and the intensity of the color is measured.

Human Anti-synaptophysin antibody (SYP-Ab) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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