ZNRD1 encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.Lepourcelet et al. (1996) identified ZNRD1, which they called HTEX6, as 1 of several genes in the HLA-A /HLA-F region of chromosome 6. The deduced protein contains 2 potential zinc-binding motifs and shows significant homology with the A12.2 subunit of yeast polymerase I and mouse Tctex6. Coriton et al. (2000) cloned ZNRD1 from a testis cDNA library. The deduced protein contains 126 amino acids. They also identified splice variants predicted to encode shorter peptides.

Human DNA-directed RNA polymerase I subunit RPA12 (ZNRD1) ELISA Kit employs a two-site sandwich ELISA to quantitate ZNRD1 in samples. An antibody specific for ZNRD1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyZNRD1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ZNRD1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ZNRD1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human DNA-directed RNA polymerase I subunit RPA12 (ZNRD1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Find more details at http://www.abbkine.com/product/human-dna-directed-rna-polymerase-i-subunit-rpa12-znrd1-elisa-kit-kte62446/

Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.