Cathepsin Z or cathepsin X is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. The predicted 303-amino acid protein has the domain structure characteristic of cysteine proteinases, including a signal sequence, a prodomain, and a catalytic domain responsible for proteolytic activity. However, it also contains 3 unique peptide insertions. Cathepsin Z shares protein sequence identity with other human cysteine proteinases of the papain family, including 34% with cathepsin C and 26% with cathepsin B.

Human Cathepsin Z (CTSZ) ELISA Kit employs a two-site sandwich ELISA to quantitate CTSZ in samples. An antibody specific for CTSZ has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyCTSZ present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CTSZ is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CTSZ bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Cathepsin Z (CTSZ) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.