NDNF is evolutionarily well conserved, being present in invertebrate animals. Multiple cysteines are conserved between species and secondary structure prediction shows that NDNF is mainly composed of beta-strands.NDNF is a glycosylated, disulfide-bonded secretory protein that contains a fibronectin type III domain. NDNF promoted migration and growth and elicited neurite outgrowth of mouse hippocampal neurons in culture. NDNF also protected cultured hippocampal neurons against excitotoxicity and amyloid beta-peptide toxicity. NDNF was exclusively expressed in the brain and spinal cord. NDNF was expressed by neurons and not by astrocytes. NDNF expression was observed in the neurons during development.NDNF is a novel neurotrophic factor derived from neurons that may be useful in the treatment of neuronal degeneration diseases and nerve injuries.

Human Fibronectin type-III domain-containing protein C4orf31 (C4orf31) ELISA Kit employs a two-site sandwich ELISA to quantitate C4orf31 in samples. An antibody specific for C4orf31 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyC4orf31 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for C4orf31 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of C4orf31 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Fibronectin type-III domain-containing protein C4orf31 (C4orf31) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.