KCNRG is a soluble protein with characteristics suggesting it forms hetero-tetramers with voltage-gated K+ channels and inhibits their function. KCNRG has been found to be predominatly expressed in lung tissue. Additionally, KCNRG transcripts are also found in liver and some other tissues, but in lower extent. Researchers at Uppsala University have found that KCNRG is found in the lower lung and constitutes an autoantigen in a rare disorder named autoimmune polyendocrine syndrome type 1 (APS1). As a subset of patients with APS1 suffer from respiratory disease, an autoimmune reaction against KCNRG may explain the respiratory disease in these patients. KCNRG may also be connected to common nonfatal diseases like asthma and chronic bronchitis.

Human Putative potassium channel regulatory protein (KCNRG) ELISA Kit employs a two-site sandwich ELISA to quantitate KCNRG in samples. An antibody specific for KCNRG has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKCNRG present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KCNRG is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KCNRG bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Putative potassium channel regulatory protein (KCNRG) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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