KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues.KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin.KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian and breast cancer patients.Based on homology between the human and mouse kallikrein loci, Yousef and Diamandis defined a 300-kb human kallikrein gene region on chromosome 19q13.3-q13.4. Within this region, they identified a new kallikrein gene, KLK9, which they designated KLKL3. The deduced 250-amino acid KLK9 protein has a predicted molecular mass of 27.5 kD and shares 40% amino acid sequence identity with KLK11.

Human Kallikrein-9 (KLK9) ELISA Kit employs a two-site sandwich ELISA to quantitate KLK9 in samples. An antibody specific for KLK9 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKLK9 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KLK9 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KLK9 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Kallikrein-9 (KLK9) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.