Keratin 16 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21.This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.

Human Keratin, type I cytoskeletal 16 (KRT16) ELISA Kit employs a two-site sandwich ELISA to quantitate KRT16 in samples. An antibody specific for KRT16 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKRT16 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KRT16 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KRT16 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Keratin, type I cytoskeletal 16 (KRT16) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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