Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function . LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades .Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Human Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) ELISA Kit employs a two-site sandwich ELISA to quantitate LILRA3 in samples. An antibody specific for LILRA3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyLILRA3 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LILRA3 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LILRA3 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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