Lysophosphatidic acid receptor 1 is a G protein-coupled receptor which binds the lipid signaling molecule lysophosphatidic acid (LPA). Hence this receptor is also known as LPA1.The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins.

Human Lysophosphatidic acid receptor 1 (LPAR1) ELISA Kit employs a two-site sandwich ELISA to quantitate LPAR1 in samples. An antibody specific for LPAR1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyLPAR1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LPAR1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LPAR1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Lysophosphatidic acid receptor 1 (LPAR1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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