LRRC4B is a synaptic adhesion protein. It regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and LAR regulates excitatory synapse formation in a bidirectional manner.LRRC4 are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. Mature LRRC4 family members are type I transmembrane proteins with an extracellular region that contains nine LRRs, a C2-type Ig-like domain, and a Thr-rich segment. LRRC4 family members share ~55% aa identity, but each recognizes different ligands. LRRC4 and LRRC4C recognize Netrin-G2 and Netrin-G3, respectively, while LRRC4B recognizes the receptor tyrosine phosphatases LAR/PTPRF, PTPR delta and PTPR sigma.

Human Leucine-rich repeat-containing protein 4B (LRRC4B) ELISA Kit employs a two-site sandwich ELISA to quantitate LRRC4B in samples. An antibody specific for LRRC4B has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyLRRC4B present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LRRC4B is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LRRC4B bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Leucine-rich repeat-containing protein 4B (LRRC4B) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.