Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.By screening with sequences based on those of the rat ERK3 gene, Lechner et al. (1996) isolated an ERK6 clone from a human skeletal muscle cDNA library. They reported that ERK6 appears to function as a signal transducer during differentiation of myoblasts to myotubes. Li et al. (1996) stated that SAPK3 is probably identical to the ERK6 gene cloned by Lechner et al. (1996).

Human Mitogen-activated protein kinase 12 (MAPK12) ELISA Kit employs a two-site sandwich ELISA to quantitate MAPK12 in samples. An antibody specific for MAPK12 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyMAPK12 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for MAPK12 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of MAPK12 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Mitogen-activated protein kinase 12 (MAPK12) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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