Progressive diversification of paralogs after gene expansion is essential to increase their functional specialization. However, mode and tempo of this divergence remain mostly unclear. PRDM7 underwent major structural rearrangements that decreased the number of encoded Zn-Fingers and modified gene splicing. Through internal duplication and activation of a non-canonical splice site (GC-AG), PRDM7 can acquire a novel intron. PRDM7 is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Human Probable histone-lysine N-methyltransferase PRDM7 (PRDM7) ELISA Kit employs a two-site sandwich ELISA to quantitate PRDM7 in samples. An antibody specific for PRDM7 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPRDM7 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PRDM7 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PRDM7 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Probable histone-lysine N-methyltransferase PRDM7 (PRDM7) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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