Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus. Agitoxin-2 technical information AA sequence: Gly-Val-Pro-Ile-Asn-Val-Ser-Cys8-Thr-Gly-Ser-Pro-Gln-Cys14-Ile-Lys-Pro-Cys18-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn-Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OH Disulfide bonds: Cys8-Cys28; Cys14-Cys33; Cys18-Cys35 Length (aa): 38 Formula: C169H278N54O48S8 Molecular Weight: 4090.89 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: 168147-41-9 Source: Synthetic Purity rate: > 97 %

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