Ligand exchange is the preferred method for the chromatographic analysis and separation of many sugars and sugar alcohols due to the advantage of simply using water as eluent. In ligand exchange, the negatively charged hydroxy groups in carbohydrate molecules interact with the positively charged metal containing groups on the chromatography substrates. The carbohydrates are eluted by polar water mobile phase.

Nano-Micro has developed a complete line of high performance chromatographic media for the analysis and separation of carbohydrates. The media are prepared by sulfonating poly(styrene-co-divinylbenzene) microspheres followed by chelating of various metal ions such as calcium (Ca²⁺) and sodium (Na⁺).

Nano-Micro’s high performance analysis resins provide high resolution and high efficiency separation of carbohydrates, alcohols and organic acids because of their precisely controlled particle size and extremely narrow particle size distribution. The particle size can be selected from 5, 6, 8, 10, 20, and 100 μm with cross-linking degree at 5%, 8%, or 10%. These high stable resins provide high resolution, low back pressure, and reliable lot-to-lot reproducibility.

Cationic resin for the analysis and separation of carbohydrate and organic acid

SEM pictures of poly(styrene-co-divinylbenzene) microspheres

Product List

Nano-Micro Tech is devoted to developing a world-leading technology for making the highest quality and the largest selection of uniformly sized nano- and microparticles. The company is capable of supplying monodisperse particles of any size in the range from 5 nanometers to 1000 microns. Current products include high performance chromatographic media and columns, solid phase extraction (SPE) sorbents, metal scavenger resins, LCD spacer, particle size standards, enzyme support, drug carriers, ACF conductive particles, magnetic particles, fluorescent microspheres, light diffuser particles, cosmetic additive particles and various functional microparticles for other applications.

The company has a 3500 square meter manufacturing plant and 3000 square meter R&D lab in Suzhou Industrial Park. Microparticles from Nano-Micro Tech have already been broadly used worldwide in biopharmaceuticals, nano and microparticle calibration standards, LED, medical diagnosis, flat panel displays, enzyme catalysis, cosmetics, etc.

Nano-Micro Tech is a state certified New and High Technology Enterprise, and SGS ISO9001:2008 registered company.