SNX-482, Selective blocker of Cav2.3 channel SNX-482 has been isolated from the venom of the Spider Hysterocrates gigas (African tarantula). SNX-482 modulates the R-type current associated with the class α1E calcium channel (Cav2.3 from the CACNA1E gene). SNX-482 antagonizes channel activation by inducing a depolarizing shift in the activation potential, thus preventing the channel from undergoing normal membrane depolarization. SNX-482 acts rapidly and maintains its effect. SNX-482 technical information AA sequence: Gly-Val-Asp-Lys-Ala-Gly-Cys7-Arg-Tyr-Met-Phe-Gly-Gly-Cys14-Ser-Val-Asn-Asp-Asp-Cys20-Cys21-Pro-Arg-Leu-Gly-Cys26-His-Ser-Leu-Phe-Ser-Tyr-Cys33-Ala-Trp-Asp-Leu-Thr-Phe-Ser-Asp-OH Disulfide bonds: Cys7-Cys21, Cys14-Cys26 and Cys20-Cys33 Length (aa): 41 Formula: C192H274N52O60S7 Molecular Weight: 4496.42 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: 203460-30-4 Source: Synthetic Purity rate: > 95 % http://www.smartox-biotech.com/en/calcium-channel/128-snx482

Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.