ShK - Stichodactyla toxin, Kv1.3 blocker ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM. Shk technical information AA sequence: Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OH Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32 Length (aa): 35 Formula: C169H274N54O48S7 Molecular Weight: 4054.85 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: 165168-50-3 Source: Synthetic Purity rate: > 97% http://www.smartox-biotech.com/en/potassium-channel/147-shk

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