Phrixotoxin-2 / PaTx2, Blocker of Kv4.2 and Kv4.3 channels Phrixotoxin-2 (PaTx2) has been isolated originally from the venom of the Chile fire tarantula Phrixotrichus auratus. Phrixotoxin-2 is a 31 amino acid peptide that contains three disulphide bridges. Phrixotoxin-2 specifically blocks recombinant Kv4.2 and Kv4.3 currents with IC50 values of 34 nM and 71 nM, respectively. It does so by altering the gating properties of the channels. The inhibition of Kv4.2 and Kv4.3 currents is fully reversible upon washout. Kv4.1 is only slightly sensitive to Phrixotoxin-2 (maximal block of 20 by 300 nM). Kv1, Kv2 and Kv3 channel subfamilies are insensitive to this toxin Phrixotoxin-2 technical information AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Arg-Ile-Ile-Asn-Met-NH2 Disulfide bonds:Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25 Length (aa): 31 Formula: C169H259N49O43S8 Molecular Weight: 3921.71 Da Appearance: white lyophilized solid Solubility: water or saline buffer CAS number: 221889-63-0 Source: Synthetic Purity rate: > 98% http://www.smartox-biotech.com/en/potassium-channel/310-phrixotoxin-2

Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.