Margatoxin, Kv1.3 selective blocker Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 µM concentration. Margatoxin is known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50 around 1 nM). Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM. Margatoxin technical information AA sequence: Thr-Ile-Ile-Asn-Val-Lys-Cys7-Thr-Ser-Pro-Lys-Gln-Cys13-Leu-Pro-Pro-Cys17-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys29-Met-Asn-Gly-Lys-Cys34-Lys-Cys36-Tyr-Pro-His-OH (Disulfide bonds between Cys7-Cys29, Cys13-Cys34 and Cys17-Cys36) Length (aa): 39 Formula: C178H286N52O50S7 Molecular Weight: 4179.03 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: [145808-47-5] Source: Synthetic Purity rate: > 97 % http://www.smartox-biotech.com/en/potassium-channel/141-margatoxin

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