Iberiotoxin, Blocker of high conductance Ca2+-activated K+ channel Iberiotoxin (IbTx) is a toxin that was originally isolated from Buthus tamulus scorpion venom. Iberiotoxin inhibits selectively the high conductance Ca2+-activated K+ channel (KCa1.1) at nanomolar concentrations (IC50 ~2 nM). This toxin does not affect other types of calcium-dependent or voltage-dependent K+ channels. Iberiotoxin is a valuable tool to study specifically Maxi-K channels. Iberiotoxin technical information AA sequence: pGlu-Phe-Thr-AspVal-Asp-Cys-Ser-Val-Ser-Lys-GIu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-GIn-OH Disulfide bridges: Cys7-Cys28, Cys13-Cys33, Cys17-Cys35 Length (aa): 37 Formula: C179H274N50O55S7 Molecular Weight: 4230.8 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: 129203-60-7 Source: Synthetic Purity rate: > 95 % http://www.smartox-biotech.com/en/potassium-channel/227-iberiotoxin

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