α Conotoxin IMI, α7 nAChR selective blocker α-conotoxin IMI (alpha-conotoxin IMI) has been isolated from the venom of the cone snail Conus imperialis. α-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). α-conotoxin IMI is a selective blocker of α7 homomeric nicotinic acetylcholine receptors (IC50 ~ 200 nM). It has no effect on nAChRs composed of α2/ß2, α3/ß2, α4/ß2, α2/ß4, α3/ß4, or α4/ß4 subunits. α-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog. α-conotoxin IMI technical information AA sequence: Gly-Cys2-Cys3-Ser-Asp-Pro-Arg-Cys8-Ala-Trp-Arg-Cys12-NH2 Disulfide bonds: Cys2-Cys8 and Cys3-Cys12 Length (aa): 12 Formula: C52H78N20O15S4 Molecular Weight: 1352.92 Da Appearance: White lyophilized solid Solubility: water or saline buffer CAS number: [156467-85-5] Source: Synthetic Purity rate: > 95 % http://www.smartox-biotech.com/en/acetylcholine-receptor/75--conotoxinimi

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