µ-conotoxin CnIIIC, Selective blocker of Nav1.4 channels µ-conotoxin CnIIIC has been isolated from the venom of the marine cone snail Conus consors. µ-conotoxin CnIIIC exhibits a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). µ-conotoxin CnIIIC also blocks Nav1.2 channels (1 µM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. µ-conotoxin CnIIIC also blocks the α3β2 nicotinic acetylcholine receptor (IC50 = 450 nM) and to lesser extents the α7 and α4β2 subtypes. µ-conotoxin CnIIIC completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM). µ-conotoxin CnIIIC technical information AA sequence: Pyr-Gly-Cys3-Cys4-Asn-Gly-Pro-Lys-Gly-Cys10-Ser-Ser-Lys-Trp-Cys15-Arg-Asp-His-Ala-Arg-Cys21-Cys22-NH2 Disulfide bonds: Cys3-Cys15, Cys4-Cys21 and Cys10-Cys22 Length (aa): 22 Formula: C92H141N35O28S6 Molecular Weight: 2375.8 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: Source: Synthetic Purity rate: > 97 % See also conotoxin PIIIA and conotoxin GIIIB http://www.smartox-biotech.com/en/sodium-channel/314-conotoxin-cniiic

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