α-Conotoxin GI, Blocker of nAChRs expressed on postsynaptic membranes α-conotoxin GI (alpha-conotoxin GI) has been isolated from the venom of the cone snail Conus geographus. α-conotoxin GI acts on postsynaptic membranes and binds to the nicotinic acetylcholine receptor (nAChR). α-conotoxin GI inhibits nAChR currents. The highest affinity site is for the α/δ site on mouse muscle-derived BC3H-1 receptor, and the other site (α/γ site) on nicotinic receptors from Torpedo californica electric organ. α-conotoxin GI technical information AA sequence: Glu-Cys2-Cys3-Asn-Pro-Ala-Cys7-Gly-Arg-His-Tyr-Ser-Cys13-NH2 Disulfide bonds: Cys2-Cys7, Cys3-Cys13 Length (aa): 13 Formula: C55H80N20O18S4 Molecular Weight: 1437.61 Da Appearance: White lyophilized solid Solubility: water or saline buffer CAS number: [76862-65-2] Source: Synthetic Purity rate: > 95 % http://www.smartox-biotech.com/en/acetylcholine-receptor/82--conotoxingi

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