BeKm-1, Selective blocker of ERG1 channel BeKm-1 toxin is a peptide toxin that has been isolated from the venom of the Central Asian scorpion Buthus eupeus. BeKm-1 toxin has been reported to be a highly selective inhibitor of the human ether-a-go-go ERG1 channel (hERG1). BeKm-1 inhibits hERG1 channels expressed in HEK-293 cells with an IC50 of 3.3 nM, but has no effect at 100 nM on human EAG, human SK1, rat SK2, human IK, human BK, KCNQ1/KCNE1, KCNQ2/KCNQ3, and KCNQ4 channels. It has also minimal effects on rat ELK1 channel. BeKm-1 inhibits the human ERG1 + KCNE1 combination transiently expressed in HEK-293 cells with an IC50 value in the range of 10 to 30 nM. BeKm-1 toxin preferentially blocks human ERG channel through the closed (resting) state, although some open channel blockade is also reported to occur. BeKm-1 technical information AA sequence: Arg-Pro-Thr-Asp-Ile-Lys-Cys7-Ser-Glu-Ser-Tyr-Gln-Cys13-Phe-Pro-Val-Cys17-Lys-Ser-Arg-Phe-Gly-Lys-Thr-Asn-Gly-Arg-Cys28-Val-Asn-Gly-Phe-Cys33-Asp-Cys35-Phe-OH Disulfide bonds: Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35 Length (aa): 36 Formula: C174H261N51O52S6 Molecular Weight: 4091.70 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: Not available Source: Synthetic Purity rate: > 97% http://www.smartox-biotech.com/en/potassium-channel/285-bekm1-erg-channel-blocker

Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.