Agatoxin IVA properties

ω-agatoxin IVA is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that ω-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for ω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-_1A Ca2⁺ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.

Product specifications

AA sequence: Lys-Lys-Lys-Cys⁴-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys¹²-Lys-Trp-Gly-Gly-Thr-Pro-Cys¹⁹-Cys²⁰-Arg-Gly-Arg-Gly-Cys²⁵-Ile-Cys²⁷-Ser-Ile-Met-Gly-Thr-Asn-Cys³⁴-Glu-Cys³⁶-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH
(Disulfide bonds between Cys⁴-Cys²⁰, Cys¹²-Cys²⁵, Cys¹⁹-Cys³⁶ and Cys²⁷-Cys³⁴)
Length (aa): 48
Formula: C₂₁₇H₃₆₀N₆₈O₆₀S₁₀
Molecular Weight: 5198.44 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 145017-83-0
Source: Synthetic
Purity rate: > 97 %

Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.