Application
Exposure tests of inhalation infection, inhalation immunity, inhaler R&D in ABSL-3 and ABSL-4 laboratories.

Description
 The instrument is nose-only aerosol inhalation infection equipment for rodents combined with high-level biosafety protection. Key components are nose-only exposure system and Class III BSC cabinet. Applicable to nose-only exposure tests for rodents (e.g., mice, rats, guinea pigs, ferrets, rabbits, etc.) with same dose under non-anesthesia conditions. Meanwhile, Class III BSC cabinet keeps personnel, laboratory and atmosphere safe during virulent pathogens tests.

Features

1.  Animal adaptability: mice, rats, guinea pigs, ferrets, rabbits etc.
2. Exposure environment monitoring: exposure room temp, humidity, pressure difference, carbon dioxide concentration, and oxygen concentration can be monitored in real-time during tests, compliant with the requirements of inhalation guidelines.
3. Parameters real-time monitoring: aerosol generation flow rate, dilution flow rate, sampling flow rate, pumping flow rate, poisoning time, remaining time, etc.
4. Adopt a high-precision gas mass flow controller, which fully meets the requirements of gas flow accuracy in inhalation exposure tests.
5. Class III BSC cabinet: compact design in stainless steel, excellent corrosion resistance, large rounded corners ensure no cleaning of dead corners. Double-sided design allows multi-users to operate together.
6. Integrated safety design: integrated design of the Class III BSC cabinet and exposure tower mainly includes safety program coordinated control, sterilization and purification program setting, corrosion-resistant sensors, double HEPA filtration, intelligent pressure difference control, internal and external interlock, startup self-test, etc.
7. Advanced technology platform: simulate natural infection of respiratory pathogen, provide an advanced evaluation platform for pathogenic microorganism inhalation infection, vaccine aerosol immunity, lung drug delivery and aerosol challenge evaluation for vaccine or drug.
8. Nose-only inhalation infection: avoid other exposure pathways such as digestive tract and skin, which conform to the natural infection pathway of respirator

Specification
 

Dimensions of Class III BSC cabinet	Less than 3100*900*2250mm
Dimensions of Class III BSC cabinet working area	1794*835*900mm
Operation sides of Class III BSC cabinet	Double-sided
Filter precision	H14
Noise	Lower than 67db
Exposure ports of 2 layers exposure tower	24 ports
Flow rate of 3-hole aerosol generator	6L/min
Particle size of liquid aerosol	MMAD1-3μm, GSD:1.5-3
Humidity of exposure chamber during test	monitorable
Oxygen concentration in exposure chamber	monitorable
Carbon dioxide concentration in exposure chamber	monitorable

Standard

• RB∕T 199-2015 Technical code for evaluating biosafety performanceof laboratory equipment
• OECD TG 403 Acute Inhalation Toxicity (2009)
• OECD TG 436 Acute Inhalation Toxicity; Acute Toxic Class Method (2009)
• OECD TG 412 28d Sub-acute inhalation (2018)
• OECD TG 413 90d Sub-chronic inhalation (2018)

Beijing Huironghe Technology Co., Ltd. was founded in 2010 and is situated in the Beijing Economic and Technological Development Zone. As a national high-tech enterprise, the company is dedicated to developing, producing, and providing technical services for scientific research instruments and equipment related to inhalation toxicology, genetic toxicology, and aerosol detection. Its extensive portfolio of offerings includes cutting-edge products such as aerosol inhalation exposure equipment, fully automatic QuEChERS instruments, NGI, and respiratory simulators. With a steadfast commitment to technological innovation at its core, Huironghe strives to provide global customers with the most advanced and high-quality inhalation toxicology equipment and premium technical services, while continuously pushing the boundaries of research and development.