Millistak+® HC Pro (High Capacity Synthetic Media) is a synthetic depth filter providing a cleaner and more consistent depth filtration media over current diatomaceous earth (DE) and cellulose (CE) based filter media. Multiple media grades are available for primary and secondary clarification as well as downstream filtration applications.

Features & Benefits

Synthetic materials of construction
• Reduced TOC extractables and a 50% reduction in the recommended pre-use
flush volumes
• No beta glucans to interfere with limulous amoebocyte lysate (LAL) testing
for bacterial endotoxins
• Lot to lot consistency for successful development and implementation of
robust clarification processes

Depth filter media formulation & design
• Provide as much as two times the filtration capacity with equivalent filter
retention properties over commercial DE-based benchmarks
• Improved HCP impurity clearance

Disposable Pod device
• Flexible, modular format offers scalability from 5 up to 20,000 liters
• Robust device format; easy to use and set up

Millistak+® HC Pro Pod series
Millistak+® HC Pro synthetic depth filters are available in 3 media grades for primary and secondary clarification and downstream processing steps to protect chromatography columns.

Reduced Flushing Recommendations
The synthetic materials of construction used in Millistak+® HC Pro Pods are clean and exhibit a consistent depth filtration performance with reduced TOC extractables. Pre-use flush volume recommendations are reduced by 50%.

Elimination of beta glucan interference with LAL assay
No extractable beta-glucans to interfere with limulous amoebocyte lysate (LAL) testing for bacterial endotoxins.

Enhanced Filtration Performance
Millistak+® HC Pro synthetic depth filters provide as much as two times the filtration capacity of commercial
DE-based benchmarks with equivalent filter retention properties.

Impurity Clearance
Improved clearance of HCP during clarification may positively impact subsequent downstream process steps.
A slight increase in mAb product purity has been observed in both protein A bind/elute and anion exchange
flow-through chromatography (AEX F/T) process steps.