For multiple myeloma, many of the commonly detected genetic aberrations are translocations involving immunoglobulin heavy chain (IgH) switch regions (chromosome 14q32). This probe set consists of a 3’ orange probe designed to hybridize to the upstream segment of IgHG1 constant region, and a 5’ green probe which encompasses part of the variable region. Rearrangements resulting from cytogenetic events should be detected by translocation of the green probe. 

Empire Genomics has developed a custom probe set to chromosome location 14q32 which can be used to detect IGH gene translocations using fluorescence in situ hybridization (FISH). The probe comes labeled in orange and green, and generally ships within 24 hours. You can choose to customize the probe to meet your needs, which will ship right after production of the probe is complete (approximately 1 week).

Probe Details

Gene:	IGH (Orange 5-TAMRA dUTP & Green 5-Fluorescein dUTP)
Loci:	14q32
Test Kits:	20

The leading supplier of molecular diagnostics for customization and production of FISH probes, aGCH assays and upcoming new technologies to be used by Reference labs, Academic labs, Pharma, CRO’s
and Pharma /Biotech companies around the world.

Our companion Diagnostics will allow you to :
-Validate Bio-markers (signature identification and resistance).
-Identify and qualify the aberration at the Chromosomal level of specific population.
-Follow up the result of therapeutic treatment (monitoring, compound profiling, drug response, patient stratification and safety)
-Compare with the result of your current technology.
-Be translated into the initial phase of your diagnostics development toward new FDA filings (pre-clinical through clinical trial development).