The Sonata XT has the same great features as the Sonata mid-scale peptide synthesizer with double the capacity!  The Sonata XT features 0.5 or 1 L amino bottle sizes and new reaction vessel sizes up to 4.2 L!  The Sonata XT is specifically designed for automated solid phase synthesis of gram to near kilogram quantities of peptide with a multitude of solvents.  All reactions occur in an inert environment to minimize side reactions.  Seven solvent ports and twenty reagent ports allow easy customization of any synthesis protocol.  Several fluid-filling methods and mixing modes can be selected to optimize performance.  To minimize disposal costs, two waste ports allow waste streams to be separated.  A collection port can be implemented for cleavage product or valuable reagent recovery for maximum versatility.  Automated continuous monitoring of all system requirements, solvents, waste tanks, and fluid transfer assures fail-safe operation.

Features:

Flexible Methods and Modes
The Sonata XT has chemically inert, optimized channels allowing high solution transfer rates (> 400 mL/min) of any solvent.  All reactions occur in an inert environment to minimize side reactions.  Multiple mixing modes including sparging, recirculation and mechanical agitation which can be combined to maximize reaction efficiency.  Several fluid-filling methods can be selected to optimize performance.

Ideal for Custom Chemistry Requirements
Seven solvent ports and twenty reagent ports allow easy customization for any synthesis protocol.  Two volumetric vessels allow precise aliquots of all solvents/reagents to be delivered.  To minimize disposal costs, two waste ports allow waste streams to be separated.  A collection port can be implemented for cleavage product or valuable reagent recovery for maximum versatility.

Simple Software
Versatile, easy to use Windows-based software allows the experienced chemist or novice operator complete control of all aspects of synthesis.  Complete documentation of all operations occurs once synthesis is initiated.

Proven Reliability
The Sonata XT uses the same patented matrix valve components as the Symphony^® Peptide Synthesizer which has proven to be extremely reliable in the field since its introduction in February 1993.  Automated continuous monitoring of all system requirements, solvents, waste tanks, and fluid transfer assures fail-safe operation.

Specifications:

Synthesis Scale:		0.25 - 200.0 mmol (up to ~400 grams of resin)
Reaction Vessels:		Standard sizes: 200 mL, 500 mL, 1.2 L, 2 L, 3.2 L, 4.2 L
Chemistry:		Solid phase synthesis (e.g. peptide, combinatorial, small organic molecules)
Activation Schemes:		In-situ; pre-activation; experimental
Reagents/Solvents:		One pumped solvent (1 to 200 L supply) Six pressurized solvents (0.5 to 20 L each) Twenty additional reagents (0.5 L or 1 L each)
Fluid Measurement:		Two interchangeable volumetric vessels; fill by time or fill to top of reaction vessel
Solution Transfer:		Nitrogen or Argon pressure (a pump is used for the primary solvent)
Solution Removal:		Filtration
Waste Containers:		Two (20 L standard; 200 L optional) with float switches
Agitation:		Adjustable sparging; recirculation; variable oscillation.
Computer:		PC, MS Windows based
Interface:		RS232
Power:		105-125/210-250 volts, 50/60 Hz
Dimensions:		35 inch Wide x 60 inch Height x 24 inch Depth (81.3 cm W x 153 cm H x 61 cm D)

Protein Technologies, Inc. (PTI) was founded in 1985 by researchers affiliated with the University of Arizona in Tucson. In 1990, we launched our first peptide synthesizer, the PS3™, and since then we have manufactured and sold the world's finest solid phase synthesizers.

The PS3™ peptide synthesizer met with immediate success and continues to be one of the most reliable, cost effective, and easy to use instruments on the market today.

In 1993 we introduced the Symphony®, a fully automated peptide synthesizer featuring 12 independent reaction vessels that has dominated the multi-channel solid-phase synthesis market. The Symphony® is ideal for custom peptide synthesis because individual reaction vessels may be started, paused, or stopped regardless of what the other reaction vessels are doing, making it equivalent to 12 separate synthesizers in one! The Symphony® is widely regarded as perhaps the finest synthesizer available, and there are hundreds of Symphonys®operating worldwide.


In 1996 we introduced the Sonata®, a large scale automated peptide synthesizer. We included the well-established fluid movement of the Symphony®, as well as its ease of use, reagent optimization, and automated cleavage. We also added a mechanical agitator to assist nitrogen bubbling in order to efficiently mix large amounts of resin in the larger reaction vessels. The Sonata® can produce from grams to near-kilograms of expected product. In 2009, we introduced the Sonata® XT which doubles the capacity of the original Sonata® peptide synthesizer!


In 2000 we introduced the Quartet™, a 4 channel version of the Symphony® peptide synthesizer. It has all of the advantages of the Symphony® and it can be upgraded to the full Symphony® if the user's needs should grow.


In 2006, we introduced the Prelude®, a 6-channel parallel peptide synthesizer that features no-prime deliveries and extra amino acid bottles for expensive monomer additions. It can also rinse your reaction when an error occurs and send an E-mail status report to your computer or cell phone.

In 2007, we introduced the Tribute®, a revolutionary 2-channel parallel peptide synthesizer featuring a full-color chemical-resistant touchscreen, a 101-position amino acid vial rack, amino acid barcode scanning, fully-adjustable vortex and nitrogen mixing, as well as individual user logging. It also features E-mail notification and washing on error like the Prelude®. In 2009, we added the unique IntelliSynth™ UV-Monitoring and Feedback Control System to the Tribute® peptide synthesizer, which is the only UV-Monitoring system that monitors during the deprotection reaction, so it can control both the deprotection time as well as the number of repeats. In 2012, we added infrared (IR) heating to the Tribute®, giving it the fastest time to temperature of any heating technology on the market today! In addition, unlike other rapid heating methods, infrared heating can be performed on more than one reaction vessel at once, and is compatible with vortex mixing, so you can be sure you have an even temperature profile throughout your reaction vessel. Other heated systems that rely on nitrogen mixing may have hot and cold spots, which could compromise the consistency of your chemistry.

In 2010, we introduced the Overture™ robotic peptide library synthesizer. The Overture™ is the most flexible robotic platform on the market today. In addition to powerful library generation tools, the Overture™ is the only robotic platform that supports multiple, simultaneous protocols, the synthesis of different scales at the same time, and on-board automated cleavage without user intervention!

In 2012, we introduced the Symphony® X. With twice the number of reaction vessels as the original Symphony®, the Symphony® X can synthesize up to 12 peptides using preactivation or up to 24 peptides using in situ activation! It also features up to 40 amino acid positions, no-prime deliveries for expensive reagent additions, infrared heating, UV-monitoring, E-mail notification and more! With its 12 independent reactor pairs, the Symphony® X is the perfect instrument for peptide production or protocol optimization.


We have built our company on the belief that our products must be the highest possible quality, and we support our products with a dedicated field service team. We are proud of our reputation for reliability and value the trust our customers and partners have placed in PTI. Today we continue to grow and innovate to serve the needs of the peptide synthesis community.