Designed to keep up with current demands of peptide researchers
Peptide synthesis demands have changed over the years.  The use of precious, specialized amino acids creates unique challenges in instrument design.  The expectation of improved speed and throughput has made traditional synthesizers slow and wasteful.  The Prelude™ was designed to satisfy both of these needs in a compact, bench-top design.  The Prelude is perfect for special monomer additions because it has extra amino acid positions and its Single-Shot delivery feature can deliver the entire contents of any amino acid vial without wasting a drop! The Prelude also features fast fluid deliveries and frugal solvent usage.

Features：

6 Parallel Reaction Vessels
Improve your synthesis throughput dramatically.  Perfect for making families of peptides.

27 Amino Acid Positions
Add in those special monomers and amino acids without sacrificing standard reagents.

Low Prime Volumes and Solvent Usage
Efficiently uses expensive reagents, allowing greater automation capacity.

Top-Down Washing
Efficiently rinses your reaction between steps.
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Adjustable Nitrogen Mixing
The Prelude™ features fully adjustable nitrogen mixing.  The control knob is conveniently located on the front of the instrument.
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Automated Cleavage & Collection
Choose to cleave immediately (Fmoc only), at the end of a synthesis, or at a specified date and time.  Cleaved peptides are collected in convenient 50 mL centrifuge vials.  Just add ether directly to the collection vial and centrifuge to precipitate your peptide!
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Single-Shot™ Delivery Feature
Delivers the entire contents of the special 10 mL Single-Shot™ amino acid vial to the reaction vessel of your choice without priming or wasting a drop!
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Personalized User Databases
Individual users can create their own programs, peptide sequences, and syntheses that can only be accessed from their own personalized user database.  Individual databases can be stored on the instrument, or on a portable USB drive!

E-mail Notification Feature
Have the Prelude™ send an email to your computer or cell phone at a specified program step, at the beginning of each cycle, or when an error occurs.

Safe Response Feature
The Prelude™ can rinse and drain your reaction with a solvent of your choice if your synthesis is interrupted for any reason.

Dynamic Sequence Programming
Need more flexibility?  The Dynamic Sequence Programming option allows the reaction vessels to operate semi-independently.  Have one peptide run a special cycle in the middle of a sequence while the other reaction vessels sit idle!  Add pre- or post-processing cycles.  Or add or remove amino acids from a peptide sequence.

Specifications：

Synthesis Scale:	5 umol to 5.6 mmol (up to 2 g of resin per RV)
Reaction Vessels:	6 (10 mL, 45 mL)
Chemistry:	Solid phase synthesis (e.g. peptide, peptoid, PNA, DNA, combinatorial, small organic molecules)
Activation Schemes:	In-situ; experimental
Reagents/Solvents:	Eight pressurized solvents (1 to 4 L each) Twenty-seven additional reagents (10 mL, 120 mL, 400 mL bottles available)
Fluid Measurement:	Fixed loop measurement with optical sensors for amino acids and reagents, timed delivery of solvents
Solution Transfer:	Nitrogen or Argon pressure. Top down rinse.
Solution Removal:	Filtration
Waste Container:	(20 L) with float switch
Agitation:	Nitrogen bubbling - adjustable
Interface:	Proprietary Prelude control software, internal CPU, external keyboard, mouse and flat panel monitor
Power:	115/230 volts, 50/60 Hz
Dimensions:	26 inch Wide x 31.5 inch Height x 21 inch Depth (66 cm W x 80 cm H x 53 cm D)
Weight:	Approximately 100 lbs. (45 kg)
Warranty:	One year, parts and labor
Optional:	Dynamic Sequence Programming E-mail Notification

Protein Technologies, Inc. (PTI) was founded in 1985 by researchers affiliated with the University of Arizona in Tucson. In 1990, we launched our first peptide synthesizer, the PS3™, and since then we have manufactured and sold the world's finest solid phase synthesizers.

The PS3™ peptide synthesizer met with immediate success and continues to be one of the most reliable, cost effective, and easy to use instruments on the market today.

In 1993 we introduced the Symphony®, a fully automated peptide synthesizer featuring 12 independent reaction vessels that has dominated the multi-channel solid-phase synthesis market. The Symphony® is ideal for custom peptide synthesis because individual reaction vessels may be started, paused, or stopped regardless of what the other reaction vessels are doing, making it equivalent to 12 separate synthesizers in one! The Symphony® is widely regarded as perhaps the finest synthesizer available, and there are hundreds of Symphonys®operating worldwide.


In 1996 we introduced the Sonata®, a large scale automated peptide synthesizer. We included the well-established fluid movement of the Symphony®, as well as its ease of use, reagent optimization, and automated cleavage. We also added a mechanical agitator to assist nitrogen bubbling in order to efficiently mix large amounts of resin in the larger reaction vessels. The Sonata® can produce from grams to near-kilograms of expected product. In 2009, we introduced the Sonata® XT which doubles the capacity of the original Sonata® peptide synthesizer!


In 2000 we introduced the Quartet™, a 4 channel version of the Symphony® peptide synthesizer. It has all of the advantages of the Symphony® and it can be upgraded to the full Symphony® if the user's needs should grow.


In 2006, we introduced the Prelude®, a 6-channel parallel peptide synthesizer that features no-prime deliveries and extra amino acid bottles for expensive monomer additions. It can also rinse your reaction when an error occurs and send an E-mail status report to your computer or cell phone.

In 2007, we introduced the Tribute®, a revolutionary 2-channel parallel peptide synthesizer featuring a full-color chemical-resistant touchscreen, a 101-position amino acid vial rack, amino acid barcode scanning, fully-adjustable vortex and nitrogen mixing, as well as individual user logging. It also features E-mail notification and washing on error like the Prelude®. In 2009, we added the unique IntelliSynth™ UV-Monitoring and Feedback Control System to the Tribute® peptide synthesizer, which is the only UV-Monitoring system that monitors during the deprotection reaction, so it can control both the deprotection time as well as the number of repeats. In 2012, we added infrared (IR) heating to the Tribute®, giving it the fastest time to temperature of any heating technology on the market today! In addition, unlike other rapid heating methods, infrared heating can be performed on more than one reaction vessel at once, and is compatible with vortex mixing, so you can be sure you have an even temperature profile throughout your reaction vessel. Other heated systems that rely on nitrogen mixing may have hot and cold spots, which could compromise the consistency of your chemistry.

In 2010, we introduced the Overture™ robotic peptide library synthesizer. The Overture™ is the most flexible robotic platform on the market today. In addition to powerful library generation tools, the Overture™ is the only robotic platform that supports multiple, simultaneous protocols, the synthesis of different scales at the same time, and on-board automated cleavage without user intervention!

In 2012, we introduced the Symphony® X. With twice the number of reaction vessels as the original Symphony®, the Symphony® X can synthesize up to 12 peptides using preactivation or up to 24 peptides using in situ activation! It also features up to 40 amino acid positions, no-prime deliveries for expensive reagent additions, infrared heating, UV-monitoring, E-mail notification and more! With its 12 independent reactor pairs, the Symphony® X is the perfect instrument for peptide production or protocol optimization.


We have built our company on the belief that our products must be the highest possible quality, and we support our products with a dedicated field service team. We are proud of our reputation for reliability and value the trust our customers and partners have placed in PTI. Today we continue to grow and innovate to serve the needs of the peptide synthesis community.