Peripheral myelin protein 22, also known as PMP22, is a protein encoded by the PMP22 gene. Alternative splicing of this gene results in three transcript variants that encode the same protein.The integral membrane protein encoded by this gene is a hydrophobic, tetraspan glycoprotein expressed mainly in Schwann cells and is a major component of compact myelin in the peripheral nervous system.Various mutations of the gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and Hereditary neuropathy with liability to pressure palsies (HNPP).
Rat Peripheral myelin protein 22 (PMP22) ELISA Kit employs a two-site sandwich ELISA to quantitate PMP22 in samples. An antibody specific for PMP22 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPMP22 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PMP22 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PMP22 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Rat Peripheral myelin protein 22 (PMP22) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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