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- eProtein DiscoveryTM instrument
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- The instrument bringing simplicity and automation to your bench
Rapidly prototype proteins on your bench, on your terms. The eProtein DiscoveryTM instrument streamlines protein project workflows by automating and optimizing screening, expression, and characterization of drug targets.
Features and Benefits
With protein prototyping, you can draw a straight line from theory to reality, allowing you to test hypotheses more efficiently and focus on promising targets. The eProtein DiscoveryTM instrument puts rapid protein prototyping on your benchtop.
Designed for all levels of scientist, it streamlines your workflow and grants you the ability to identify optimal DNA constructs, test expression feasibility earlier, and pursue targets with confidence. Fail fast, succeed faster!
Rapidly produce protein
Turn DNA into purified, soluble, active proteins in 48 hours — not weeks. Why wait when you don’t have to!
Multiplex constructs and conditions
Simultaneously screen 192 combinations of constructs and expression conditions.
Save time with automation
Integrate screening, characterization, and report generation. Time is on your side.
Examples of proteins synthesized with eProtein Discovery™
Protein Class
Cytokines/Growth Factors
Protein Name
. Interferon gamma (IFN-γ)
. Programmed cell death protein 1 (PD1)
. Erythropoietin
. Vascular endothelial growth factor (VEGF)
. Interleukin-2 (IL-2)
Kinase/Phosphatases
Protein Name
. Phosphoglycerate kinase (PGK)
. Mixed lineage kinase domain like pseudokinase (MLKL)
. PTPN2
Antibodies
Protein Name
. Nanobody
Transcription Factors
Protein Name
. GATA-1
. c-Jun
Other Enzymes
Protein Name
EC 1 Oxidoreductases
.Dihydrofolate reductase (DHFR)
.Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
.Glyceraldehyde-3-phosphate dehydrogenase A
.Superoxide dismutase [Mn]
.Thioredoxin reductase
EC 2 Transferases
.Arylamine N-acetyltransferase 1
.Terminal deoxynucleotidyl transferase (TdT)
.Class I SAM-dependent methyltransferase
.Maltodextrin phosphorylase (MalP)
Transketolase 1
.Protein arginine methyltransferase 1 (PRMT1)
.Ubiquitin ligase (MDM2)
EC 3 Hydrolases
.3C-like protease (MPro (229E))
.Lysozyme C
.Periplasmic serine endoprotease DegP-like
.Thermolysin
.Angiotensin-converting enzyme 2 (ACE2)
EC 4 Lyases
.Carbonic anhydrase 1 (CA1)
.Enolase
.Lactoylutathione lyase
.Pyruvate decarboxylase
.EC 5 Isomerases
.Phosphoglucose isomerase (PGI)
Technical Specifications
| Imaging System | 20MP CMOS camera with unique lighting system |
| Bead Handling | 32 automated bead handling zones |
| Thermal Control | 15-50 °C Cartridge Thermal Control |
| Display | 12.1 in 1024x728 px touchscreen |
| Automation/Motion Control | Automated 80 nl precision droplet control |
| Instrument Dimensions (in) | 14.5" (W) x 19.9" (D) x 17" (H) |
| Instrument Dimensions (cm) | 37 cm (W) x 50.5 cm (D) x 43 cm (H) |
| Temperature and Humidity | 59-86°F, 15-30°C (<80% non condensing humidity) |
| Weight | ≈ 40 pounds (18 kg) |
| Input Power | 100-240 V, 50/60 Hz |
| Noise Output | ≤ 52 dB(A) in operating mode (less than conversation) |
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Nuclera is driven by the mission to better human health by increasing accessibility to proteins. We are committed to providing rapid access to high-quality, soluble, active proteins at the benchtop allowing researchers to accelerate their protein projects, enabling faster success.
Using Nuclera’s eProtein Discovery™ system scientists can automate construct screening to inform off-platform protein scale-up, delivering reliable protein in-hand (μg-mg amounts) in less than 48 hours. Nuclera’s technology integrates cell-free protein synthesis and digital microfluidics on smart cartridges, allowing rapid progress on protein projects through a benchtop, automated, high-throughput protein access system.
Founded in 2013 by PhD students at the University of Cambridge, the company now has a presence in Cambridge, UK and Boston, MA employing over 100 employees.
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