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Illumina Launches VeriSeq PGS

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Next-Generation Sequencing Solution for Preimplantation Genetic Screening Offers Increased Scalability

SAN DIEGO--Apr. 29, 2014-- Illumina, Inc. (NASDAQ:ILMN) today announced the launch of VeriSeqTM PGS, a next-generation sequencing (NGS) solution developed for preimplantation genetic screening (PGS) of embryos using Illumina鈥檚 NextSeqTM 500 and MiSeq® sequencing systems. The offering brings together the industry-leading Illumina 24sure array-based platform for PGS with Illumina鈥檚 next-generation sequencing (NGS) technology to offer laboratories a more scalable PGS solution.

鈥淏ringing the high-throughput capabilities of Illumina鈥檚 NGS systems to PGS will enable IVF clinics to offer the latest technology to their patients,鈥 said Simon Fishel, CEO of CARE Fertility Group. 鈥淰eriSeq PGS has the potential to improve pregnancy success rates for couples using IVF by identifying chromosomally normal embryos for implantation.鈥

PGS has been clinically proven as an effective means to select chromosomally normal embryos, increasing pregnancy success rates for in vitro fertilization (IVF) procedures.1,2 VeriSeq PGS complements the 24sure array-based assay, using the same sample preparation and BlueFuse software workflows. The NGS-based assay leverages Illumina鈥檚 sequencing systems and enables reference laboratories to perform PGS using a platform that meets their throughput needs.

鈥淰eriSeq PGS showed a high level of consistency with the established 24sure technology,鈥 said Francesco Fiorentino, Ph.D., Founder and Lab Director, GENOMA Laboratory. 鈥淚 recently did a comparison study between the 24sure assay and VeriSeq PGS to assess the accuracy of an NGS-based test for aneuploidy screening on single cells. NGS-based aneuploidy screening appears to be a robust methodology ready to find a place in routine clinical application.鈥

鈥淰eriSeq PGS demonstrates Illumina鈥檚 continuing commitment to reproductive and genetic health. By developing and providing accessible tools to perform PGS, we hope to enable reference laboratories to offer these services worldwide,鈥 said Tristan Orpin, Senior Vice President and General Manager of Reproductive and Genetic Health forIllumina. 鈥淲e want to offer these groups a complete reproductive health portfolio so they can better support physicians and their patients in pursuit of successful pregnancies.鈥

The new VeriSeq PGS solution on the MiSeq sequencing system will begin shipping in June, and the solution for the NextSeq 500 sequencing system will begin shipping later in 2014. For more information, visitwww.illumina.com/VeriSeqPGS.

About Illumina

Illumina (www.illumina.com) is a leading developer, manufacturer, and marketer of life science tools and integrated systems for the analysis of genetic variation and function. We provide innovative sequencing and array-based solutions for genotyping, copy number variation analysis, methylation studies, gene expression profiling, and low-multiplex analysis of DNA, RNA, and protein. We also provide tools and services that are fueling advances in consumer genomics and diagnostics. Our technology and products accelerate genetic analysis research and its application, paving the way for molecular medicine and ultimately transforming healthcare.

Forward-Looking Statements
This release may contain forward-looking statements that involve risks and uncertainties. Important factors that could cause actual results to differ materially from those in any forward-looking statements are detailed in our filings with the Securities and Exchange Commission, including our most recent filings on Forms 10-K and 10-Q, or in information disclosed in public conference calls, the date and time of which are released beforehand. We do not intend to update any forward-looking statements after the date of this release.

1 Yang Z, Liu J, Collins GS, Salem SA, Liu X, et al. (2012) Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet 5(1): 24.

2 Harton GL, Munn茅 S, Surrey M, Grifo J, Kaplan B, et al. (2013) Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization. Fertil Steril 100(6): 1695鈥1703.

Source: Illumina, Inc.

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