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Fluidigm Completes C1™ Single-Cell Auto Prep System Early Access Program

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Oversubscribed Program Includes World鈥檚 Leading Research Centers

SOUTH SAN FRANCISCO, Calif. 鈥 Jan. 2, 2013 鈥 Fluidigm Corporation (NASDAQ:FLDM) announced that its C1™ Single-Cell Auto Prep system Early Access Program (EAP) has concluded. The EAP originally targeted 25 customers that would gain early access to the new platform, protocols and consumables. The program attracted significant interest, filling up weeks before its expected end-of-2012 deadline.  To accommodate interested customers, the company allowed oversubscription of the program.

 "We have been excited and humbled by the enthusiastic reception the C1 system has received. Our customers have demonstrated a high level of interest in the C1 Early Access Program and the number of them that have signed up to participate is clearly a record for Fluidigm,鈥 said Gajus Worthington, Fluidigm President and Chief Executive Officer. 鈥淭he C1 system is the most powerful device for single-cell genomics available today because it enables a wide range of genomic applications for our customers to discover and validate novel transcripts in heterogeneous cell populations. We are just at the beginning stages of an important market that will fuel genomic discovery over the next decade.鈥

The C1 Single-Cell Auto Prep System enables researchers to study cell differentiation, measure individual cell responses to specific stimuli, verify critical disease biomarkers, validate RNAi knockdown, and conduct candidate drug screens. 鈥淲e are thrilled to be working with an elite set of customers in our Early Access Program. They represent a global group of scientists from the world鈥檚 leading genomics research institutions. They have a genuine enthusiasm about the prospect of applying C1 system capabilities to their research and many have begun experimental design and initial work on the systems. We believe they will generate some breakthrough biological discoveries,鈥 added Worthington.

"As one of the first academic users of the Fluidigm C1 Single Cell Auto Prep system, my research team at UC San Diego will benefit by the development of this advanced, single-cell technology.  The system will support our commitment to engaging our expertise in RNA and genome-wide computational methods to deciphering heterogeneity in RNA processing in single cells, especially in the developing nervous system and in neurodegenerative diseases,鈥 noted Gene Yeo, PhD, MBA, Assistant Professor, Department of Cellular and Molecular Medicine, UC San Diego.

鈥淪ingle-cell analyses are critical for our cellular reprogramming research because each cell undergoes a fate change in a unique way. Averaging the changes over many cells masks important reprogramming events in individual cells that dramatically alter their fate,鈥 said Deepak Srivastava, Director of Cardiovascular and Stem Cell Research, Gladstone Institutes. 鈥淲e are thrilled to be part of the Fluidigm C1 Single-Cell Auto Prep System鈥檚 Early Access Program and look forward to using this exciting new technology to accelerate our single-cell research efforts.鈥

鈥淲e are delighted to be one of the first users of the Fluidigm C1 system. One of our first projects will involve the analysis of neurons directly converted from skin fibroblasts. The C1 system will allow us to look at markers specific for subtypes of neurons at a single-cell resolution while assessing the conversion rate collectively in the population of converted neurons,鈥 said Seth Crosby, Director, Partnerships and Alliances at Washington University School of Medicine. 鈥淭he Fluidigm C1 Single-Cell Auto Prep System will be available in our facility on a fee-for-service basis for both WashU and non-WashU researchers,鈥 Crosby added.

鈥淭he C1 system allows us to capture up to 96 individual cells at one time and prepare them for further analysis,鈥 says Vivian Gersuk, PhD, manager of the Genomics Core Laboratory of the Benaroya Research Institute. 鈥淲e can study hundreds to thousands of genes in each of these cells, allowing us to produce huge amounts of data in a matter of hours.鈥

The C1 Single-Cell Auto Prep System is the first commercially available platform for automated isolation and preparation of individual cells for genomic analysis. The C1 system, based on Fluidigm鈥檚 innovative microfluidic technology, enables a researcher to isolate, process and summarize the unique gene expression profiles of individual cells rapidly and reliably. For the first time, a researcher can easily isolate single cells, extract RNA, then reverse transcribe and amplify mRNA transcripts to ultimately detect and analyze cell activity 鈥 dramatically reducing the variability and technical errors caused by multi-platform workflows that have been previously used.  By delivering an integrated workflow, Fluidigm is enabling researchers to implement targeted gene expression, miRNA analysis and whole transcriptome analysis in a more efficient and cost-effective manner. 

Fluidigm鈥檚 Early Access Program for the C1 system provided a select group of customers with the preferred access of instruments equipped with a package of startup consumables (integrated fluidic circuits (IFCs) and reagents), and provides first access to new application protocols or analysis tools. The EAP participants actively contribute information about their experiences with the C1 system to Fluidigm to accelerate the development of new platform capabilities. The C1 system is specifically designed to work seamlessly with the Fluidigm BioMark™ HD System to enhance the workflow and reliability of data for scientists studying single-cell genomics.

The C1 Single-Cell Auto Prep System consists of:
    • C1 Single-Cell Auto Prep instrument that provides breakthrough bench-top automation of isolation, lysis and amplification performed on single cells.
    • C1 Single-Cell Auto Prep Array IFCs that facilitate capture and highly paralleled preparation of up to 96 individual cells.
    • C1 Single-Cell Auto Prep Reagent Kit, a pre-formulated 鈥渞eady to use鈥 reagent kit that supports cell suspension, lysis and purification.

For more information about the C1 Single Cell Auto Prep system, please visit www.fluidigm.com/c1system.

Use of Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to Fluidigm鈥檚 new C1 system, Fluidigm鈥檚 expectations with respect to the development of a market for single cell genomic analysis and discovery, Fluidigm鈥檚 plans, objectives, expectations and strategies relating to the C1 system, and potential developments in the markets that the C1 system is anticipated to target. Forward-looking statements are subject to numerous risks and uncertainties that could cause actual results to differ materially from currently anticipated results, including challenges inherent in developing, manufacturing, and launching new products and risks relating to research and development activities and the growth of new and developing markets.  Information on these and additional risks affecting Fluidigm鈥檚 business and operating results are contained in its filings with the Securities and Exchange Commission, including its most recently filed Quarterly Report on Form 10-Q for the quarter ended September 30, 2012. These forward-looking statements speak only as of the date hereof and Fluidigm disclaims any obligation to update these statements.

About Fluidigm
Fluidigm (NASDAQ:FLDM) develops, manufactures and markets microfluidic systems for growth markets in the life science and agricultural biotechnology, or Ag-Bio, industries. Fluidigm鈥檚 proprietary microfluidic systems consist of instruments and consumables, including integrated fluidic circuits (IFCs), assays and other reagents. These systems are designed to significantly simplify experimental workflow, increase throughput and reduce costs, while providing the excellent data quality demanded by customers. Fluidigm actively markets four microfluidic systems, including thirteen different IFCs, to leading academic institutions, diagnostic laboratories, and pharmaceutical, biotechnology and Ag-Bio companies. Fluidigm products are marketed for research purposes only (not for diagnostic use).  

For more information, please visit www.fluidigm.com.

Fluidigm, the Fluidigm logo, C1 and BioMark, are trademarks or registered trademarks of Fluidigm Corporation.  All other trademarks are the property of their respective owners.


Howard High 鈥 Press Relations
Fluidigm Corporation
650.266.6081 (office)
510.786.7378 (mobile)

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